What nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time?

What nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time?
Q1)Using Question 9.2 in the textbook, what nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time? Explain in your own words what the answer means.
Q2)Using Question 9.3 in the textbook, implement the procedure in Question 9.2 and report a p-value. Explain in your own words what the answer means
Q3) Using Question 9.11 in the textbook, what nonparametric test can be used to determine whether a significant change in periodontal status has occurred over time? Explain in your own words what the answer means
Q4) Using Question 10.22 in the textbook, is the distribution of stage at disease significantly different between Caucasians and African American women with breast cancer who are younger than 50 years of age? What were the null and alternative hypotheses? Explain in your own words what the answer means
Q5) Using Question 10.24 in the textbook, is there any relationship btween the types of treatment and the response? What are the null and alternative hypotheses? Explain in your own words what the answer means
Q6) Using Question 10.52 in the textbook, what is the reproducibility of adverse events and negligence designations (be sure to answer both)? Which seems to be more reproducible – adverse events or negligence designations? Explain in your own words what your answer means.

 
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